Protein Details: Calcium-activated chloride channel regulator 1
Protein ID
ICDB_Pro_0068
Protein Name
Calcium-activated chloride channel regulator 1
Gene Name
CLCA1; CACC1
Organism
Homo sapiens (Human)
Length
914 amino acids
AlphaFoldDB
AF-A8K7I4-F1-model_v4.pdb
Function
May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia; mucus hypersecretion; cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC.
Sequence
Ligand Binding
Binding Site
BINDING 156; /ligand="Zn(2+)"; /ligand_note="catalytic"; BINDING 160; /ligand="Zn(2+)"; /ligand_note="catalytic"; BINDING 167; /ligand="Zn(2+)"; /ligand_note="catalytic";
Disease
Pontocerebellar Hypoplasia;Type 8 and Cystic Fibrosis
Location
Highly expressed in small intestine and colon namely in intestinal basal crypt epithelia and goblet cells; and appendix. Weakly expressed in uterus; testis and kidney. Expressed in the airways epithelium of both asthmatic and healthy patients. Expressed in the airways epithelium of both asthmatic and healthy patients. Expressed in the airways epithelium of both asthmatic and healthy patients. Expressed in the bronchial epithelium; especially in mucus-producing goblet cells. Expressed in normal turbinate mucosa and nasal polyp. Expressed in.
DOI ID
10.1006/geno.1998.5562; 10.1016/s0014-5793(99)00891-1; 10.1038/ng1285; 10.1038/nature04727; 10.1074/jbc.m112.410282; 10.1089/10445490152122442; 10.1164/ajrccm.165.8.2107068; 10.1067/mai.2002.121555; 10.1080/00016480510028519; 10.1016/j.jaci.2004.09.039; 10.1074/jbc.m504654200; 10.1165/rcmb.2004-0220rc; 10.1159/000104419
RefSeq
NP_001276.2